My name is Ângela França, I’m a Biologist and currently I’m a PhD student at the University of Minho, Braga, Portugal.
My PhD thesis is focused on the Staphylococcus epidermidis biofims and their interactions with the host immune system.
I’m integrated in a team directed by Nuno Cerca at the Centre of Biological Engineering.
Quick Curriculum vitae
2009-2013 – PhD in Biomedical Engineering at the Centre of Biological Engineering, University of Minho.
January 2009-Febrary 2009 – Colaboration with National Cancer Institute – Nanotecnhology Characterization Laboratory, Frederick, Maryland, USA. Here, I studied the different phagocytic routes involved in the uptake of gold nanoparticles by macrophages. This work was supervised by África González-Fernández and Marina Dobrovolskaia.
2007-2008 – Master in Clinical Biology by the University of Trás-os-Montes e Alto Douro. The Master thesis was developded inn the Immunology laboratory at the University of Vigo, Spain. Here, I studied the evaluation of the citotoxicity of gold nanoparticles in different human cell lines and, also, I have tested the consequences of different sterilization procedures in the stability of gold nanoparticles. This work was supervised by África González-Fernández and Maria dos Anjos Clemente Pires.
2003-2007 – Degree in Biology by the University of Trás-os-Montes e Alto Douro,Vila Real, Portugal. I did my curricular training in the University of Porto (ICBAS) working in the celullar and molecular characterization of the immune system response to Streptococcus agalactiae infections promoted by either the challenge of the bacterium or their excreted proteins. My training was developed under the supervision of Delfina Tavares, Dario Santos and Gabriela Trigo.
Publications in per-review journal
A. França M. Vilanova, N. Cerca, G.B. Pier (2013) Monoclonal antibody raised against PNAG present variable effect in S. epidermidis biofilm accumulation in vitro. International Journal of Biological Sciences, 9:518-520.
N. Cerca , F. Gomes, J.C. Bento , A. França, J. Rolo, M. Miragaia, P. Teixeira, R. Oliveira (2013). Farnesol induces cell detachment from established S. epidermidis biofilms. Journal of Antibiotics, in press.
A. França, A.I. Freitas, A. F. Henriques, N. Cerca (2012) Optimizing a qPCR Gene Expression Quantification Assay for S. epidermidis Biofilms: A Comparison between Commercial Kits and a Customized Protocol. PloS One, 7(5):e37480.
A. França, J. Bento, N. Cerca (2012) Variability of RNA Quality Extracted from Biofilms of Foodborne Pathogens Using Different Kits Impacts mRNA Quantification by qPCR. Current Microbiology, 65:54-59.
A. França, LDR Melo, N. Cerca.(2011) Comparison of RNA extraction methods from biofilm samples of Staphylococcus epidermidis. BMC Research Notes 4(1): 572.
F. Cerca, A. França, R. Guimaraes, M. Hinzmann, N. Cerca, A. Lobo da Cunha, J. Azeredo, M. Vilanova. (2011) Modulation of poly-N-acetylglucosamine accumulation within mature Staphylococcus epidermidis biofilms grown in excess of glucose. Microbiology and Immunology 10(55): 673-682.
F. Cerca , F. Andrade, A. Franca, E.B. Andrade, A. Ribeiro, A.A. Almeida, N. Cerca, G. Pier, J. Azeredo, M. Vilanova. (2011) Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages. J Med Microbiol, 60(12): 1717-24
A. França, A. Aggarwal, E. V. Barsov, S. V. Kozlov, Á. González-Fernández, M. A. Dobrovolskaia and S. McNeil. (2011) Macrophage Scavenger Receptor A Mediates the Uptake of Gold Colloids in vitro. Nanomedicine, 6(7):1175-88.
A. França, B. Pelaz, M. Moros, C. Sánchez-Espinel, A. Fernández, C. Fernández-López, V. Grazú, J. M. de La Fuente, I. Pastoriza Santos, L. M. Liz-Márzan and Á. González-Fernández. (2010) Sterilization matter: Consequences of different sterilization techniques on gold nanoparticlce. Small, 6: 89-95.
G. Trigo, M. Dinis. A. França, E. B. Andrade, R. M. Gil da Costa, P. Ferreira and D. Tavares. (2009) Leukocyte population and cytokine expression in the mammary gland in a mouse model of Streptococcus agalactiae mastitis. Journal of Medical Microbiology, 58: 951-958.